Venetoclax Powder

1.Name: Venetoclax Powder
2.Appearance:White powder
3.Specification: 98% min
4.CAS No.:1257044-40-8
5.Molecular Formula：C45H50ClN7O7S
6.Product Grade: Pharmaceutical grade
7.Payment Method:T/T Western Union/Alibaba Online/Visa
8.Certificates: FDA,Organic,Kosher, ISO, HALAL, HACCP, GMP
9.Transport Package:1kg Aluminum Foil Bag/25kg Drum
10.Factory situation:Two Factories & Three production lines.GMP standard workshop & two independent laboratories.
11.Storage method:Dry and cool place
12.MOQ:100g
13.Service: powder, capsule, customized order
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Product Description

Products Description

Venetoclax

 

 
Venetoclax

Venetoclax is an oral drug with the chemical name (2S)-1-[4-(4-amino-3-piperonyl)phenyl]-1-(4-amino-2-oxopyridin-1-yl)propanone. It is a small molecule BCL-2 inhibitor, mainly used to treat chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML).


Venetoclax appears as a white or off-white solid in solution, with a chemical formula of C_45H_50Cl_N_7_O_7_S and a molecular weight of 868.44 g/mol. Its melting point is 137-139°C, and it is easily soluble in methanol and dichloromethane, but insoluble in water.

 

COA

Venetoclax COA

 

Application
Venetoclax

 

is primarily used for the treatment of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML), specifically in patients who have certain genetic mutations and have not responded to other treatments. It is also being investigated for potential use in other types of cancers, such as non-Hodgkin's lymphoma and multiple myeloma.

Mechanisms of response/resistance to venetoclax. (A): Mutations associated with favorable response to venetoclax. (B): Mutations associated with resistance to venetoclax. (C): Monocytic differentiation is associated with resistance to venetoclax. Monocytic differentiation of AML blasts is associated with downregulation of BCL2, whereas other proapoptotic proteins are upregulated. (D): Leukemic cells rely on amino acids for metabolization in the TCA cycle and subsequent OXPHOS. Venetoclax/azacytidine inhibits amino acid processing. Switching to fatty acid oxidation is a potential mechanism of resistance. VEN/AZA: venetoclax/azacytidine; AA: amino acid; FAO: fatty acid oxidation; OXPHOS: oxidative phosphorylation. Created with BioRender.com.
 
Chronic lymphocytic leukemia (CLL)
Acute myeloid leukemia (AML)
Multiple myeloma

 

 

 

  • When it comes to chronic lymphocytic leukemia (CLL), Venetoclax is approved for the treatment of adult patients whose disease has relapsed after at least one treatment. Usually, Venetoclax is used in combination with an anti-CD20 antibody drug, such as Rituximab. It is also usually used in patients with a specific genetic change (17p short arm deletion) or in patients who have relapsed after treatment.
  • For acute myeloid leukemia (AML), Venetoclax is usually used in combination with other anticancer drugs, such as cytotoxic drugs, and is used to treat older patients or patients with certain genetic changes, such as FLT3 changes.
  • In patients with these specific types of leukemia, the use of Venetoclax has been shown to significantly improve patient outcomes and has brought new treatment options to patients who have become resistant to other treatments. This treatment option usually requires evaluation by a specialist to ensure optimal treatment and safety.
How to use 

Venetoclax USE

 

  • Venetoclax is usually taken as an oral tablet. But be sure to take the drug according to your doctor's prescription and instructions. Generally, the starting dose of Venetoclax will be determined by the doctor based on the patient's specific situation and will be gradually adjusted under early monitoring of treatment.
  • Patients should take Venetoclax strictly according to their doctor's advice, without changing the dose, frequency or stopping the use of the drug unless otherwise instructed by the doctor.
  • Venetoclax is usually used with other drugs, such as anticancer drugs or other anticancer treatments, which requires strict compliance with the doctor's advice and prescription. At the same time, patients may need regular blood tests and other tests to ensure the efficacy and safety of the drug.
Contact us

For further inquiries or to request a quotation for Venetoclax Powder. and other pharmaceutical raw materials, If you want to buy Venetoclax Dihydrochloride ., please feel free to reach us at sasha_slsbio@aliyun.com.We are dedicated to meeting your customized needs and providing reliable solutions for your pharmaceutical manufacturing requirements.

Quality Standards and Certification

At Salispharm, we are committed to upholding the highest standards of quality and safety in our products. Our Alpha amylase . meets the following quality standards and certifications:

salis

  •  FDA-Salis: Approved by the Food and Drug Administration (FDA) and Salispharm for quality and efficacy.
  • HALAL: Certified as compliant with Halal dietary requirements.
  • ISO: Conforms to the International Organization for Standardization (ISO) standards for quality management systems.
  • CCRE5: Complies with the standards set by the China Chemical Registration Center for Environmental Management.
  • USDA Organic: Certified organic by the United States Department of Agriculture (USDA).
  • EU Organic: Certified organic by the European Union.
Packaging and Transportation
Package

painstakingly bundled to guarantee item trustworthiness and soundness during transportation.

Foil bag

Foil bag

Suitable for packaging from 1kg to 25kg

Samples are usually placed in sealed inner packaging bags to protect the quality and safety of the samples. The inner packaging bags are usually aluminum foil bags or plastic bags, which can effectively isolate air and moisture and maintain the stability of the samples.

Vial

Suitable for packaging in mg

The vials of APIs have a sealed property to ensure that the APIs are not contaminated or deteriorated during storage and transportation, thereby ensuring the quality of the APIs. The vials usually have labels with information about the APIs, such as batch number, specification, production date, expiration date, etc.

API VIAL

Cardboard barrel

Cardboard barrel

For use with more than 25kg

Cardboard barrels are light, strong and environmentally friendly, and can effectively protect the contents from damage and contamination. Cardboard barrels usually have lids to allow them to be closed and sealed to ensure the safety of the contents during transportation and storage.

 
Why Choose Us?

 When it comes to sourcing pharmaceutical raw materials.like Spectinomycin Dihydrochloride , Salispharm stands out as the preferred choice for discerning buyers worldwide. Here's why:

factory

  • Mature R&D Team: Our experienced research and development team is dedicated to continuous innovation, ensuring that we stay at the forefront of pharmaceutical ingredient technology.
  • GMP Factory: Our state-of-the-art Good Manufacturing Practice (GMP) certified facility guarantees the highest standards of quality and safety in the production of nevirapine dosis and other pharmaceutical ingredients.
  • Large Inventory: With a robust inventory management system in place, we maintain ample stock levels of nevirapine dosis to meet your demand promptly.
  • Complete Certificates: Salispharm products come with a comprehensive range of certifications, including FDA, HALAL, ISO, CCRE5, USDA Organic, EU Organic, ensuring compliance with international regulatory standards.
  • OEM Support: We offer OEM services, enabling you to customize dosage forms according to your specific requirements. Whether it's tablets, capsules, or suspensions, we have the capability to deliver tailored solutions to suit your needs.
  • Fast Delivery: We understand the importance of timely delivery. Our efficient logistics network ensures swift and reliable transportation of nevirapine dosis to your doorstep.
  • Secure Packaging: Our products are securely packaged to preserve their integrity during transit, minimizing the risk of damage or contamination.
FAQ

1. Who are we?

We are based in Xian, China, start from 2020,sell to Domestic Market(45.00%),Western Europe(10.00%),EasternAsia(10.00%),North America(10.00%),Africa(5.00%),Central America(5.00%),Southeast Asia(5.00%),South America(5.00%),Mid East(5.00%). There are total about 51-100 people in our office.

2. How can we guarantee quality?

Always a pre-production sample before mass production; Always final Inspection before shipment;

3. What can you buy from us?

Fluorescent whitening agents, pigments and dyes, pharmaceutical intermediates, paint decoration, pharmaceutical impurities and other products.

4.Why should you buy from us not from other suppliers?

RD &marketing experience products are exported to Europe, North and South America, the Middle East, Asia Pacific and Africa area, so as to establish a long-term and stable cooperation relationship with customer in the world.

5.What services can we provide?

Accepted Delivery Terms: FOB,CFR,CIF,EXW,FAS,CIP,CPT,DDU,Express Delivery; Accepted Payment Currency:USD,EUR,CNY; Accepted Payment Type: T/T,L/C,D/P D/A,Western Union,Cash; Language Spoken:English,Chinese.

Contact us

For further inquiries or to request a quotation for Venetoclax. and other pharmaceutical raw materials, If you want to buy Spectinomycin Dihydrochloride , please feel free to reach us at sasha_slsbio@aliyun.com.We are dedicated to meeting your customized needs and providing reliable solutions for your pharmaceutical manufacturing requirements.

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