Pure Pregnenolone is an important intermediate for the synthesis of progesterone, finasteride, etc. It is used in the synthesis of steroid drug intermediates and steroid drugs.
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ITEMS | SPECIFICATION | RESULTS | |
---|---|---|---|
BP2010 /EP6 | Appearance | crystalline powder | Conforms |
Melting point | About 205°C | 206.4°C~206.7°C | |
Identification | Meet the requirements | Conforms | |
Appearance of solution | Clear, not more intense than Y7 | Conforms | |
PH | 2.4~3.0 | 2.60 | |
Loss on drying | ≤0.5% | 0.04% | |
Sulphated ash | ≤0.1% | 0.01% | |
Heavy metals | ≤20 ppm | <20 ppm | |
Related substances | ≤0.25% | Conforms | |
Assay | 99.0%~101.0% | 99.8% | |
USP32 | Identification | Meet the requirements | Conforms |
Loss on drying | ≤0.5% | 0.04% | |
Residue on ignition | ≤0.1% | 0.01% | |
Heavy metals | ≤0.003% | <0.003% | |
Residue solvent - Ethanol | ≤0.5% | <0.04% | |
Chloride | 16.9%~17.6% | 17.1% | |
Assay | 98.0%~102.0% | 99.8% |
1. Role in Anxiety and Depression
Research suggests that pregnenolone may play a role in regulating anxiety and depression.
In one study, people who took pregnenolone subjectively reported a reduction in depression ratings.
In this study, researchers found an interesting finding in a subgroup of study participants that seems to add additional evidence to the idea that pregnenolone is involved in the body's stress response system. They found that pregnenolone seemed to reverse the sedative effects of a single dose of the commonly used benzodiazepine diazepam (Valium). This finding suggests that pregnenolone may play a possible role in reversing the sedative-hypnotic effects of benzodiazepines, especially if the dose is inappropriate. Pregnenolone may play an important therapeutic role in managing bipolar depression (BPD).
In a randomized controlled trial, the effects of pregnenolone were investigated in 80 adults with bipolar disorder who were in a depressed mood state. Participants were evenly divided between taking pregnenolone or placebo as an add-on therapy to prescription medications for bipolar depression. In the group taking pregnenolone, participants' doses were slowly increased to 500 mg per day. Common clinical scales used to assess depressive states in BPD were used to evaluate the study participants. The authors found that depression remission was more pronounced in the group taking pregnenolone (61%) than in the placebo group (37%). Pregnenolone was well tolerated by the study participants. These results led the study investigators to conclude that pregnenolone may improve depressive symptoms associated with BPD with minimal side effects.
2. Role in Memory and Cognitive Health
Pregnenolone may play a role in improving memory and cognitive function by increasing acetylcholine levels and regulating GABA, the main inhibitory neurotransmitter in the brain.
3. Role in Psychosis Management
Research reports have found that Pregnenolone may help patients with schizophrenia by positively affecting steroid hormones in the brain. Researchers have also found evidence that Preg may increase levels of gamma-aminobutyric acid (GABA) in the brain. GABA is the main inhibitory neurotransmitter in the brain, a chemical that calms you down and naturally fights agitation.
4. Role in Neuroprotective Functions
Pregnenolone may play an integral role in protecting the central nervous system. For example, in Alzheimer's disease, Pregnenolone may reduce the amount of amyloid plaques, beta-amyloid 42 protein, and neurofibrillary tangles in the brain, which are the main toxins that contribute to the progression of this particular type of dementia.
5. Role in Chronic Pain
Recent promising research suggests that Pregnenolone may indeed help relieve pain.
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