Finasteride is a 4-azasteroid compound. It is a specific inhibitor of the intracellular enzyme type II 5a-reductase in the process of testosterone metabolism into dihydrotestosterone. It can effectively reduce dihydrotestosterone in the blood and prostate, that is, by inhibiting the conversion of testosterone into dihydrotestosterone (DHT), the prostate volume is reduced, symptoms are improved, urine flow rate is increased, and benign prostatic hyperplasia is prevented.
Finasteride is a 4-azasteroid compound that is a specific inhibitor of the intracellular enzyme type II 5α-reductase in the process of testosterone metabolism into the more powerful dihydrotestosterone. Benign prostatic hyperplasia, or prostatic hypertrophy, depends on the conversion of testosterone to dihydrotestosterone in the prostate. This drug is very effective in reducing dihydrotestosterone in the blood and prostate. Finasteride has no affinity for androgen receptors.
In a long-term efficacy and safety study of this drug (PLESS), 3016 patients with moderate to severe symptoms of prostatic hyperplasia who took this drug for 4 years were evaluated for prostatic hyperplasia-related urinary system treatment (surgical intervention), such as transurethral resection of the prostate and other prostatectomies, or acute urinary retention requiring catheterization. In this double-blind, randomized, placebo-controlled multicenter study, treatment with this drug reduced the overall risk of urinary system treatment by 51%, accompanied by significant and sustained reduction in prostate volume, as well as sustained increase in maximum urine flow rate and improvement in symptoms.
Finasteride is a 4-nitrogen steroid hormone compound and a specific type II 5α-reductase inhibitor. It inhibits the conversion of peripheral testosterone into dihydrotestosterone and reduces the level of dihydrotestosterone in the blood, prostate, skin and other tissues. The growth, development and benign hyperplasia of the prostate depend on dihydrotestosterone. Finasteride inhibits prostate hyperplasia and improves the clinical symptoms related to benign prostatic hyperplasia by reducing the level of dihydrotestosterone in the blood and prostate tissue.
COA of Finasteride Powder
Analysis | Specification | Result | Test method |
---|---|---|---|
Appearance | White Powder | White Powder | Visual |
Odor | Characteristic | Characteristic | Organoleptic |
Particle size | 90% pass 80 mesh | 90% pass 80 mesh | 80 Mesh Screen |
Assay (Lutein) | 98% | 98.15% | HPLC |
Loss on drying | 5.0% Max | 1.82% | 5g/105ºC/2hrs |
Ash Contents | 5.0% Max | 1.12% | 2g/525ºC/3hrs |
Residual Solvents | 50.0 ppm, Only Ethanol | <30.0 ppm | / |
Heavy metals | 5.0 ppm Max | <3.0 ppm | AAS |
Lead | 3.0 ppm Max | <1.0 ppm | AAS |
Arsenic | 3.0 ppm Max | <1.0 ppm | AAS |
Total Bacteria Count | 1,000cfu/g Max | <280cfu/g | AOAC |
Yeast & Mold | 100cfu/g Max | <10cfu/g | AOAC |
Coliform | 30.0 MPN/g Max | <3.0 MPN/g | AOAC |
Proscar is taken orally, 5 mg/time, once/day. 5 mg/day, can be taken in the morning and evening, before meals, and after meals. It is recommended to take it for a long time.
Patients with renal insufficiency: No dosage adjustment is required for patients with various degrees of renal insufficiency (creatinine clearance as low as 9 mL/min).
Elderly: Pharmacokinetic studies in patients over 70 years old have shown that the clearance rate of finasteride is reduced, but no dosage adjustment is required.
When finasteride is used for the treatment of hair loss, it is taken orally 1 mg/time, once/day, and 1 course of treatment is 4 months.
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