Pure Diclofenac Sodium

What is Pure Diclofenac Sodium

Pure Diclofenac Sodium is an organic compound with the chemical formula C14H10Cl2NNaO2. It is mainly used as an antipyretic and analgesic, non-steroidal anti-inflammatory drug, and is commonly used in the treatment of various mild to moderate acute and chronic pain in orthopedics, such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, etc.

Main effects of Pure Diclofenac Sodium

1. Mainly used to relieve joint swelling and pain symptoms of various arthritis such as osteoarthritis, rheumatoid arthritis, gouty arthritis, rheumatic arthritis, etc.;

2. Used to treat various non-articular soft tissue rheumatic pain, such as shoulder pain, bursitis, myalgia and pain after sports injury, etc.; used for acute mild and moderate pain such as: post-surgery, post-strain, toothache, headache, etc.; has a certain antipyretic effect on fever

Pharmacological effects of diclofenac sodium powder

Diclofenac sodium is a non-steroidal anti-inflammatory drug with obvious analgesic, anti-inflammatory and antipyretic effects. It produces analgesic, anti-inflammatory and antipyretic effects by inhibiting cyclooxygenase and blocking the synthesis of prostaglandins. Its effect is 2~2.5 times stronger than indomethacin and 26~50 times stronger than acetylsalicylic acid. It is characterized by strong efficacy, mild adverse reactions, small doses and small individual differences.

The binding rate of diclofenac sodium to plasma proteins is 99.7% and the half-life is 1~2 hours. It is administered at the recommended dose and interval without accumulation. The drug is metabolized by the liver, and about 60% of the therapeutic dose of metabolites is excreted from the kidneys, and the excretion of the original drug is less than 1%. The rest of the dose is excreted into the intestines through bile in the form of metabolites and cleared from the feces

Coa of diclofenac sodium

Application of Diclofenac Sodium Powder:

Its flexible idea makes Diclofenac sodium powder appropriate in different clinical fields, including:

• Rheumatology:Treatment of rheumatoid joint inflammation, osteoarthritis, and other rheumatic problems.

• Orthopedics:The board of outer muscle torment, including injuries, strains, and sports wounds.

• Pain Management: Relief of acute and chronic pain associated with inflammatory conditions.

• Sports Medicine: Rehabilitation of sports-related injuries and management of sports-induced inflammation.

• Dermatology: Skin treatment of confined agony and irritation, like in dermatitis and sun related burn.

Dosage and administration of diclofenac sodium

1. As a general recommendation, the dosage should be adjusted accordingly for different individuals, and the minimum effective dose should be given as short an interval as possible.

2. As a general rule, the initial daily dose for adults is 100~150mg. For mild patients who need long-term treatment, the daily dose is 75~100mg, and the daily dose is usually taken in 2~3 times. In order to reduce night pain and morning stiffness, tablets can be used for treatment during the day, and suppositories can be used for auxiliary treatment before bedtime (daily dose does not exceed 150mg).

For primary dysmenorrhea, the daily dose usually needs to be adjusted individually, generally 50~150mg, taken in divided doses. The initial dose should be 50~100mg. If necessary, the dose can be increased to a maximum dose of 200mg per day within several menstrual cycles. Treatment should be started immediately once symptoms appear and continue for several days. The treatment plan depends on the symptoms.

3. Children and adolescents

For children or adolescents aged 1 year or above, the daily dose is 0.5~2mg/kg, divided into 2~3 doses, depending on the condition. For juvenile rheumatoid arthritis, the daily dose can be up to 150mg. Due to the large dosage of 50mg and 75mg enteric-coated tablets, children and adolescents under 14 years old should not use it, but 25mg diclofenac sodium can be used. It should not be used for infants under 1 year old.

Special populations

1. Patients with severe heart failure, as well as patients with severe liver, kidney and heart failure, should not use this product.

2. This product is prohibited in the first two months of pregnancy and 3 months after pregnancy. Diclofenac sodium may damage female fertility. Therefore, this product is not recommended for women preparing for pregnancy. Women who have difficulty conceiving and are undergoing infertility tests should also consider stopping this product.

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