Irinotecan Powder

What's Irinotecan?

Irinotecan is a semi-synthetic water-soluble camptothecin derivative. This product and its metabolite SN38 are inhibitors of DNA topoisomerase I. The complex formed with topoisomerase I and DNA can cause DNA single-strand breaks, prevent DNA replication and inhibit RNA synthesis, which is the S phase of the cell cycle. Specificity.

Pharmacological effects of Irinotecan powder

Irinotecan is a semisynthetic derivative of camptothecin. It is an inactive prodrug whose main site of metabolism is the liver.

After irinotecan enters the human body through the blood, most of it is converted by carboxylesterase (CES) into the active metabolite SN-38 (7-ethyl-10-hydroxycamptothecin), which has 100 times the anti-tumor ability. Sexually combined with topoisomerase I (TOP-1), thereby achieving anti-tumor effects; the other part is converted into APC and NPC by CYP3A enzyme in liver cells, and then converted into SN-38 by CES to achieve anti-tumor effects.

Topoisomerase I induces reversible DNA single-strand breaks, thereby unwinding the DNA double-stranded structure; irinotecan and its active metabolite SN-38 can bind to topoisomerase I-DNA complexes, thereby preventing the break Single chain reconnection.

During DNA synthesis, replicase interacts with the topoisomerase I-DNA-CPT-11 triplet complex and exerts a cytotoxic effect by causing DNA double-strand breaks. Normally, mammalian cells cannot effectively repair such DNA double-strand breaks.

Irinotecan powder side effects

Common side effects of irinotecan include: delayed diarrhea (occurring within 24 hours after taking the drug), neutropenia, nausea and vomiting, and acute cholinergic syndrome (including early-onset diarrhea, occurring within 24 hours of taking the drug);

A few minor reactions include: anorexia, abdominal pain, mucositis, fatigue, and thrombocytopenia. About 20% of these patients develop severe neutropenia and/or diarrhea when receiving irinotecan-based combination chemotherapy.

The research results suggest that the toxicity of irinotecan is mainly caused by its active metabolite SN-38. SN-38 mainly binds to plasma proteins (binding rate 95%). After exerting its anti-tumor effect, active SN-38 is mainly catalyzed by UGT1A1 (uridine diphosphate glucuronosyltransferase 1A1) located in the liver. It is converted into inactive SN-38G (the activity is about 1/50~1/100 of SN-38), which is then excreted through urine and bile; at the same time, UGT1A1 can also participate in the glycosylation conversion of bilirubin. This in turn produces more soluble conjugated bilirubin.

Be sure to follow your doctor’s advice when using this product

Packaging and Transportation:

General packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 5kg/carton(5kg net weight, 5.3kg gross weight, packed in five aluminum foil bag)

3)25kg/drum (25kg net weight, 28kg gross weight;)

Contact US

If you want to buy irinotecan powder, please contact us for more details iceyqiang@aliyun.com

Why Choose Us?

Salispharm stands apart as a confided in provider of drug unrefined components for a few convincing reasons:

Experienced Research and development Group: Our organization flaunts a full grown innovative work group devoted to guaranteeing the best expectations of item quality and development.

GMP Processing plant: We work a cutting edge fabricating office that sticks to Great Assembling Practices (GMP), ensuring the consistency and virtue of our items.

Enormous Stock: With a significant stock of unrefined components, we can speedily satisfy requests of any size, furnishing our clients with adaptability and inner harmony.

Complete Testaments: Our items are joined by all fundamental endorsements, including FDA-Salis,HALAL, ISO, CCRE5, natural USDA,natural, and EU Natural accreditations, exhibiting our obligation to administrative consistence and quality confirmation.

OEM Administration: We offer far reaching OEM administrations, permitting clients to alter measurement structures and bundling as per their exceptional necessities. Furthermore, we can work with the offer of completed items for those looking for a turnkey arrangement.

Quick Conveyance: We grasp the significance of convenient conveyance and endeavor to speed up the transportation cycle, guaranteeing that our clients accept their orders instantly and proficiently.

Secure Bundling: All items are fastidiously stuffed to forestall tainting and guarantee item trustworthiness during transportation.

FAQ

Q1: Can i get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the

samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ?

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery lead time?

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)