Genipin powder

What is Genipin Powder?

Genipin powder is the product of Gardenia jasminoides hydrolyzed by β-glucosidase. It is an excellent natural biological cross-linking agent that can be cross-linked with proteins, collagen, gelatin and chitosan to make biomaterials, such as artificial bones, wound dressing materials, etc. Its toxicity is much lower than glutaraldehyde and other commonly used chemical cross-linking agents. It can also be used to treat liver diseases, lower blood pressure, and relieve constipation.

Research results show that genipin can relieve the symptoms of type II diabetes. Genipin can also be used as a fingerprint collection reagent and a cross-linking agent for preparing immobilized enzymes.

Application of Genipin Powder

Anticholinergic Activity

Genipin powder has a variety of biological activities, including protein regulation, anti-tumor, anti-inflammatory, immunosuppressive, anti-thrombotic and protection of hippocampal neurons. The substance can also be used in type 2 diabetes research. The substance has an anticholinergic inhibitory effect on gastric function. The compound has an anticholinergic inhibitory effect on gastric function and is the strongest substance among the iridoid glycosides found so far to inhibit the mutagenic activity of mutagens. Anticholinergic activity means that the compound can block or weaken cholinergic neurotransmission and inhibit the action of cholinergic nerves. This may lead to relaxation of gastrointestinal smooth muscle, thereby reducing gastrointestinal motility and delaying gastrointestinal movement.

Inhibition of Mutagenic Activity

In addition, Genipin powder also shows a strong effect in inhibiting the mutagenic activity of mutagens. Mutagens are a class of chemicals that can cause DNA mutations or other genetic variations. Inhibiting the mutagenic activity of mutagens means that the substance may be able to reduce or prevent the damaging effects of these chemicals on DNA, thereby having a potential anti-cancer effect. In addition, it can prevent lipid peroxidation and the production of nitric oxide in vivo, it can protect hippocampal neurons from the toxicity of Alzheimer's beta amyloid protein, and it also has anti-inflammatory and anti-angiogenic effects. Genipin can also participate in drug delivery systems and has a wide range of applications in basic biochemical research. It should be noted that this substance can be used as a natural product, and its specific pharmacological effects and mechanisms of anti-gastric function and inhibition of mutagenic activity of mutagens require further in-depth research and verification. However, its unique properties make it have great potential in the fields of medicine and biology, and may provide beneficial help for the treatment of gastrointestinal diseases and cancer, but when it is applied in the field of medicine, its safety and effectiveness still need to be carefully evaluated and further clinical research should be conducted.

Coa of Genipin powder

Cross-linking principle of Genipin powder

The cross-linking principle of genipin mainly involves its ring opening in an alkaline environment to form an aldehyde intermediate, which then forms a Schiff bond with the amino groups in collagen and chitosan to form a stable network structure. This process not only improves the mechanical properties of biomaterials, but also has a wide range of application potential in the biomedical field due to its natural source and low toxicity.

As a natural biological cross-linking agent, genipin can be cross-linked with biomolecules such as proteins, collagen, gelatin and chitosan, and is used to make biomaterials such as artificial bones and wound dressing materials. Its cross-linking process not only enhances the stability of the material, but also improves the material's resistance to enzymatic hydrolysis, making it of great application value in tissue engineering and other biomedical fields.

In addition, genipin has high cross-linking efficiency and significantly lower cytotoxicity than traditional synthetic chemical cross-linking agents, which makes it a better choice in the cross-linking modification of natural biomaterials. For example, in articular cartilage tissue engineering, genipin is used to improve the elastic modulus of chitosan/calcium silicate/silk fibroin composite scaffolds, so that it can be better used in clinical practice.

In summary, genipin not only enhances the mechanical properties of biomaterials through its unique cross-linking mechanism, but also shows broad application prospects in the field of biomedical engineering due to its low toxicity and good biocompatibility.

Packaging and Transportation:

At Salispharm, we focus on the no problem at all bundling of our items to guarantee their respectability during transportation. It is carefully loaded as per industry guidelines to forestall defilement and keep up with item steadiness. We offer an assortment of bundling choices to oblige different client needs and inclinations. Our effective strategies network empowers quick and dependable transportation of orders to objections around the world, guaranteeing ideal conveyance and consumer loyalty.

Quality Standards and Certifications

Our product adheres to the highest quality standards and holds numerous certifications, ensuring global recognition and trust:

FDA-Salis HALAL ISO CCRE5 USDA Organic EU Organic

Contact US

If you want to buy Genipin powder please contact us for more details iceyqiang@aliyun.com