Emtricitabine Powder

• 1. Used in combination with other antiviral drugs for the treatment of HIV-1 infection in adults. Patients are those who have not been treated with reverse transcriptase inhibitors or those whose virus has been suppressed after treatment with reverse transcriptase inhibitors.
• 2.Used for the treatment of chronic hepatitis B.

Emtricitabine is a chemically synthesized nucleoside cytosine. Its anti-HIV-1 mechanism is to form active triphosphates through multi-step phosphorylation in vivo to competitively inhibit HIV-1 reverse transcriptase, and at the same time, it competes with natural 5-phosphocytosine to penetrate into the process of viral DNA synthesis, ultimately leading to the interruption of its DNA chain synthesis. Its anti-HBV mechanism is due to the fact that the HBV replication process contains the target of emtricitabine, namely the reverse transcription process. It has weak inhibitory activity on mammalian DNA polymerase α, β, ε and mitochondrial DNA polymerase γ

Pharmacokinetic evaluation was conducted in healthy volunteers and HIV-infected individuals. The pharmacokinetics were similar in both groups.

1. Absorption: Oral administration is rapidly absorbed and widely distributed, with plasma drug concentration reaching peak value 1-2 hours after administration. Multiple doses of emtricitabine were administered orally to 20 HIV-infected patients, and the (mean ± SD) emtricitabine plasma peak concentration (Cmax) was 1.8 ± 0.7 μg/ml, and the area under the 24-hour plasma drug concentration-time curve (AUC) was 10.0 ± 3.1 hr*μg/ml. The average steady-state plasma concentration 24 hours after administration was 0.09 μg/ml. The average bioavailability was 93%. Multiple dose pharmacokinetics are proportional to the dose (25-200 mg).

2. Distribution: The binding rate of emtricitabine to human plasma proteins in vitro is <4%, and it exists in a free state when the concentration exceeds the range of 0.02-200 μg/ml. At peak concentration, the ratio of plasma to blood drug concentration is 1.0, and the ratio of semen to plasma drug concentration is 4.0.

3. Metabolism: In vitro studies have shown that emtricitabine is not a human CYP450 enzyme inhibitor. Taking 14C-labeled emtricitabine, it reaches the urine (86%) and feces (14%) in its original form. 13% of the dose is converted into three metabolites. Its biotransformation includes oxidation of the sulfhydryl part to form 3'-sulfoxide diastereomers (9%), and combining with glucuronic acid to form 2'-oxy-glucuronide (4%). Other metabolites have not yet been determined.

4.Excretion: The plasma half-life of emtricitabine is about 10 hours. The renal clearance of emtricitabine is greater than the serum creatinine clearance. It is speculated that it is excreted through glomerular filtration and tubular secretion, and there may be substances that compete with it for renal excretion.

1. Emtricitabine is mainly excreted through the kidneys, and patients with renal insufficiency should use it in reduced doses.

2. Use in pregnant and lactating women: It may have adverse effects on young children or infants, and is secreted through breast milk, so pregnant or pregnant women and lactating women should use it with caution. It is not yet known whether emtricitabine is secreted through breast milk. Due to the possibility of mother-to-child transmission of HIV and the occurrence of serious adverse reactions, lactating women treated with emtricitabine should avoid breastfeeding. Animal experiments have not shown an increase in embryonic development and malformation rates, but there is still a lack of adequate controlled studies on the use of the drug in pregnant women, so pregnant women should use it with caution.

3. Drug overdose: There is currently no antidote for emtricitabine. A clinical study occurred in 11 patients with a single dose of 1200 mg, and no serious adverse reactions were reported. The impact of overdose is unknown. Once it occurs, the patient should be monitored for toxic reactions and supportive treatment should be given if necessary.

General packaging：

1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)

2) 5kg/carton(5kg net weight, 5.3kg gross weight, packed in five aluminum foil bag)

3)25kg/drum (25kg net weight, 28kg gross weight;)

Our product adheres to the highest quality standards and holds numerous certifications, ensuring global recognition and trust:

FDA-Salis HALAL ISO CCRE5 USDA Organic EU Organic

If you want to buy Emtricitabine powder please contact us for more details iceyqiang@aliyun.com

Salispharm stands apart as a confided in provider of drug unrefined components for a few convincing reasons:

Experienced Research and development Group: Our organization flaunts a full grown innovative work group devoted to guaranteeing the best expectations of item quality and development.

GMP Processing plant: We work a cutting edge fabricating office that sticks to Great Assembling Practices (GMP), ensuring the consistency and virtue of our items.

Enormous Stock: With a significant stock of unrefined components, we can speedily satisfy requests of any size, furnishing our clients with adaptability and inner harmony.

Complete Testaments: Our items are joined by all fundamental endorsements, including FDA-Salis,HALAL, ISO, CCRE5, natural USDA,natural, and EU Natural accreditations, exhibiting our obligation to administrative consistence and quality confirmation.

OEM Administration: We offer far reaching OEM administrations, permitting clients to alter measurement structures and bundling as per their exceptional necessities. Furthermore, we can work with the offer of completed items for those looking for a turnkey arrangement.

Quick Conveyance: We grasp the significance of convenient conveyance and endeavor to speed up the transportation cycle, guaranteeing that our clients accept their orders instantly and proficiently.

Secure Bundling: All items are fastidiously stuffed to forestall tainting and guarantee item trustworthiness during transportation.

Q1: Can i get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the

samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ?

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery lead time?

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)