Cepharanthine powder is a leukocytogenic drug that can promote the proliferation of bone marrow tissue, thereby increasing white blood cells. It is used for leukocytopenia. It can increase the number of peripheral blood leukocytes. Animal experiments have found that it can significantly prevent the leukocytopenia caused by mitomycin, but does not inhibit the anti-cancer effect of mitomycin. Its mechanism of action is to promote the proliferation of bone marrow tissue, thereby increasing the number of white blood cells. It is used for agranulocytosis caused by tumor chemotherapy and radiotherapy and leukocytopenia caused by other reasons.
The pharmacological mechanism of cepharanthine is mainly to exert its effects through inhibiting platelet aggregation, anti-inflammatory and immunomodulatory effects.
1. Inhibiting platelet aggregation: Cepharanthine has a strong inhibitory effect on platelet aggregation. In clinical practice, cepharanthine is often used to treat atherosclerosis, cardiovascular and cerebrovascular diseases and other diseases caused by excessive platelet aggregation.
2. Anti-inflammatory: Cepharanthine can inhibit the occurrence and development of inflammatory reactions. Its mechanism may be related to blocking the synthesis and release of inflammatory mediators. In addition, cepharanthine can also inhibit the expression of multiple cytokines, thereby reducing tissue damage and promoting repair.
Item | Specification | Test Results |
---|---|---|
Appearance | White powder, neutral odor, highly hygroscopic | Conform |
Identification | TLC:Standard solution and test solution same spot,RF | Conform |
Assay (Dry Basis) | 98.0%--102.0% | 98.1% |
Specific Optical | -2.4°~ -2.8° | -2.71° |
PH | 4.5~7.0 | 5.3 |
Heavy Metals (As Pb) | ≤10ppm | <10ppm |
As | ≤1ppm | Not Detected |
Pb | ≤0.5ppm | Not Detected |
Cd | ≤1ppm | Not Detected |
Hg | ≤0.1ppm | Not Detected |
Related substance | Spot not bigger than standard solution spot |
No spot |
Residual solvent | 0.5% | Complies |
Water Content | <2% | 0.18% |
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